SKIRMISHER

The next wave in health care may include a brigade of medical nanobots, devices tiny enough to ride the flow of blood through the body’s arteries to a problem area. The bots might arrive at a clot, for example, and then using an internal power system, obliterate the clot with a precisely targeted drug or therapy. Designing a power source to accomplish such a task has been a challenge, but from the College of Veterinary Medicine at Cornell University comes a possible answer. The same molecular power packs that fuel sperm in their journey through the uterus and to a fallopian tube might be copied and used to keep the nanomachines running once they reach their targets.

Led by reproductive biologist Alex Travis, the engineering effort focuses on a chain of enzymes that metabolize glucose molecules into the biological fuel ATP (a process known as glycolysis), which enables sperm locomotion. Ordinarily the ATP provides sperm with enough energy to bend and flex their tails as they swim to the unfertilized egg. Travis’s plan is to copy the design of the sperm’s engine by slightly modifying a 10-enzyme glycolysis chain embedded in the sperm’s tail, and then to install it in nanobots.

Using mouse sperm, Travis has thus far modified the first two enzymes on the chain so that they bind to nickel ions attached to the surface of a tiny gold chip, which serves as a stand-in for a future nanobot. Now he needs to tweak the remaining enzymes so they can be attached too. If the spermlike motor works, it could someday use the body’s own energy source—glucose—to do such things as run super-tiny medical devices designed to release anticancer drugs or trigger the breakup of potentially deadly clots.

via: “3 ideas that are pushing the edge of science”

{Photo: Flying Penis attacks Gary Kasparov}

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